Upregulation of Neuronal Rheb(S16H) for Hippocampal Protection in the Adult Brain.
Identifieur interne : 000010 ( Main/Exploration ); précédent : 000009; suivant : 000011Upregulation of Neuronal Rheb(S16H) for Hippocampal Protection in the Adult Brain.
Auteurs : Gyeong Joon Moon [Corée du Sud] ; Minsang Shin [Corée du Sud] ; Sang Ryong Kim [Corée du Sud]Source :
- International journal of molecular sciences [ 1422-0067 ] ; 2020.
Abstract
Ras homolog protein enriched in brain (Rheb) is a key activator of mammalian target of rapamycin complex 1 (mTORC1). The activation of mTORC1 by Rheb is associated with various processes such as protein synthesis, neuronal growth, differentiation, axonal regeneration, energy homeostasis, autophagy, and amino acid uptake. In addition, Rheb-mTORC1 signaling plays a crucial role in preventing the neurodegeneration of hippocampal neurons in the adult brain. Increasing evidence suggests that the constitutive activation of Rheb has beneficial effects against neurodegenerative diseases such as Alzheimer's disease (AD) and Parkinson's disease (PD). Our recent studies revealed that adeno-associated virus serotype 1 (AAV1) transduction with Rheb(S16H), a constitutively active form of Rheb, exhibits neuroprotective properties through the induction of various neurotrophic factors, promoting neurotrophic interactions between neurons and astrocytes in the hippocampus of the adult brain. This review provides compelling evidence for the therapeutic potential of AAV1-Rheb(S16H) transduction in the hippocampus of the adult brain by exploring its neuroprotective effects and mechanisms.
DOI: 10.3390/ijms21062023
PubMed: 32188096
PubMed Central: PMC7139780
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Minsang" sort="Shin, Minsang" uniqKey="Shin M" first="Minsang" last="Shin">Minsang Shin</name><affiliation wicri:level="1"><nlm:affiliation>Brain Science and Engineering Institute, Kyungpook National University, Daegu 41566, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Brain Science and Engineering Institute, Kyungpook National University, Daegu 41566</wicri:regionArea><wicri:noRegion>Daegu 41566</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology, School of Medicine, Kyungpook National University, Daegu 41944, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Microbiology, School of Medicine, Kyungpook National University, Daegu 41944</wicri:regionArea><wicri:noRegion>Daegu 41944</wicri:noRegion></affiliation></author><author><name sortKey="Kim, Sang Ryong" sort="Kim, Sang Ryong" uniqKey="Kim S" first="Sang Ryong" last="Kim">Sang Ryong Kim</name><affiliation wicri:level="1"><nlm:affiliation>BK21 plus KNU Creative BioResearch Group, School of Life Sciences, Kyungpook National University, Daegu 41566, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>BK21 plus KNU Creative BioResearch Group, School of Life Sciences, Kyungpook National University, Daegu 41566</wicri:regionArea><wicri:noRegion>Daegu 41566</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Brain Science and Engineering Institute, Kyungpook National University, Daegu 41566, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Brain Science and Engineering Institute, Kyungpook National University, Daegu 41566</wicri:regionArea><wicri:noRegion>Daegu 41566</wicri:noRegion></affiliation></author></analytic><series><title level="j">International journal of molecular sciences</title><idno type="eISSN">1422-0067</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Ras homolog protein enriched in brain (Rheb) is a key activator of mammalian target of rapamycin complex 1 (mTORC1). The activation of mTORC1 by Rheb is associated with various processes such as protein synthesis, neuronal growth, differentiation, axonal regeneration, energy homeostasis, autophagy, and amino acid uptake. In addition, Rheb-mTORC1 signaling plays a crucial role in preventing the neurodegeneration of hippocampal neurons in the adult brain. Increasing evidence suggests that the constitutive activation of Rheb has beneficial effects against neurodegenerative diseases such as Alzheimer's disease (AD) and Parkinson's disease (PD). Our recent studies revealed that adeno-associated virus serotype 1 (AAV1) transduction with Rheb(S16H), a constitutively active form of Rheb, exhibits neuroprotective properties through the induction of various neurotrophic factors, promoting neurotrophic interactions between neurons and astrocytes in the hippocampus of the adult brain. This review provides compelling evidence for the therapeutic potential of AAV1-Rheb(S16H) transduction in the hippocampus of the adult brain by exploring its neuroprotective effects and mechanisms.</div></front></TEI><pubmed><MedlineCitation Status="In-Process" Owner="NLM"><PMID Version="1">32188096</PMID><DateRevised><Year>2020</Year><Month>04</Month><Day>11</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1422-0067</ISSN><JournalIssue CitedMedium="Internet"><Volume>21</Volume><Issue>6</Issue><PubDate><Year>2020</Year><Month>Mar</Month><Day>16</Day></PubDate></JournalIssue><Title>International journal of molecular sciences</Title><ISOAbbreviation>Int J Mol Sci</ISOAbbreviation></Journal><ArticleTitle>Upregulation of Neuronal Rheb(S16H) for Hippocampal Protection in the Adult Brain.</ArticleTitle><ELocationID EIdType="pii" ValidYN="Y">E2023</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.3390/ijms21062023</ELocationID><Abstract><AbstractText>Ras homolog protein enriched in brain (Rheb) is a key activator of mammalian target of rapamycin complex 1 (mTORC1). The activation of mTORC1 by Rheb is associated with various processes such as protein synthesis, neuronal growth, differentiation, axonal regeneration, energy homeostasis, autophagy, and amino acid uptake. In addition, Rheb-mTORC1 signaling plays a crucial role in preventing the neurodegeneration of hippocampal neurons in the adult brain. Increasing evidence suggests that the constitutive activation of Rheb has beneficial effects against neurodegenerative diseases such as Alzheimer's disease (AD) and Parkinson's disease (PD). Our recent studies revealed that adeno-associated virus serotype 1 (AAV1) transduction with Rheb(S16H), a constitutively active form of Rheb, exhibits neuroprotective properties through the induction of various neurotrophic factors, promoting neurotrophic interactions between neurons and astrocytes in the hippocampus of the adult brain. This review provides compelling evidence for the therapeutic potential of AAV1-Rheb(S16H) transduction in the hippocampus of the adult brain by exploring its neuroprotective effects and mechanisms.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Moon</LastName><ForeName>Gyeong Joon</ForeName><Initials>GJ</Initials><Identifier Source="ORCID">0000-0002-2851-9563</Identifier><AffiliationInfo><Affiliation>BK21 plus KNU Creative BioResearch Group, School of Life Sciences, Kyungpook National University, Daegu 41566, Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shin</LastName><ForeName>Minsang</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Brain Science and Engineering Institute, Kyungpook National University, Daegu 41566, Korea.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Microbiology, School of Medicine, Kyungpook National University, Daegu 41944, Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kim</LastName><ForeName>Sang Ryong</ForeName><Initials>SR</Initials><Identifier Source="ORCID">0000-0003-0299-1613</Identifier><AffiliationInfo><Affiliation>BK21 plus KNU Creative BioResearch Group, School of Life Sciences, Kyungpook National University, Daegu 41566, Korea.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Brain Science and Engineering Institute, Kyungpook National University, Daegu 41566, Korea.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>03</Month><Day>16</Day></ArticleDate></Article><MedlineJournalInfo><Country>Switzerland</Country><MedlineTA>Int J Mol 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